ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GLRX

Full Name:

glutaredoxin (thioltransferase)

Alias:

GRX|GRX1|MGC117407

Organism:

Homo sapiens (Human)

Chromosome:

5

Genetic Location:

5q14

Physical Location:

95175430-95184136 on NC_000005.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		GLRX
Original ID2:		X76648

Dataset Information

Name:		11093800
Method:		Microarray
Tissue:		SH-SY5Y neuroblastoma cells
Phenotype:		Ethanol response
Publication:		Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:		We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002064.2	NP_002055.1	NC_000005.8 range: 95175430..95184136, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	TAS (16884690)
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0015035	protein disulfide oxidoreductase activity	Molecular Function	IEA
GO:0015038	glutathione disulfide oxidoreductase activity	Molecular Function	TAS (7851394)
GO:0047485	protein N-terminus binding	Molecular Function	IPI (16884690)
GO:0006810	transport	Biological Process	IEA
GO:0045454	cell redox homeostasis	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000173221

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: