ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LpR1

Alias:

CG31094|CG31095|CG4861|CG4870|CG4874|CT15569

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

96F1-96F2

Physical Location:

21567069-21586043 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7436 Symbol (Name): VLDLR (very low density lipoprotein receptor)

Ortholog Status:

The human GeneID 7436 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	ISS
GO:0005041	low-density lipoprotein receptor activity	Molecular Function	ISS
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0008034	lipoprotein binding	Molecular Function	ISS
GO:0008203	cholesterol metabolic process	Biological Process	ISS
GO:0042953	lipoprotein transport	Biological Process	ISS