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Gene Information
Gene ID:2768852
Symbol:par-1
Alias:BcDNA:RH48823|CG11960|CG16701|CG30131|CG30132|CG8201|DPAR-1|DPar1|PAR1|anon-WO0210402.19|l(2)k06323
Organism:Drosophila melanogaster (Fly)
Chromosome:2R
Genetic Location:56D9-56D11
Physical Location:15343678-15371978 on NT_033778.3
Gene Type:protein-coding
Human Ortholog:GeneID: 4139    Symbol (Name): MARK1 (MAP/microtubule affinity-regulating kinase 1)
Ortholog Status:The human GeneID 4139 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:par-1
P Value:7.42E-03
Note:Acute up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001014539.1NP_001014539.1NT_033778.3 range: 15343678..15371978
NM_001014540.1NP_001014540.1NT_033778.3 range: 15343678..15371978
NM_001014541.1NP_001014541.1NT_033778.3 range: 15343678..15371978
NM_001014542.1NP_001014542.1NT_033778.3 range: 15343678..15371978
NM_206168.2NP_995890.1NT_033778.3 range: 15343678..15371978
NM_206169.2NP_995891.1NT_033778.3 range: 15343678..15371978
NM_206170.2NP_995892.1NT_033778.3 range: 15343678..15371978
NM_206171.2NP_995893.1NT_033778.3 range: 15343678..15371978
NM_206172.1NP_995894.1NT_033778.3 range: 15343678..15371978
NM_206173.2NP_995895.1NT_033778.3 range: 15343678..15371978
NM_206174.2NP_995896.1NT_033778.3 range: 15343678..15371978
NM_206175.2NP_995897.1NT_033778.3 range: 15343678..15371978
NM_206176.2NP_995898.1NT_033778.3 range: 15343678..15371978
NM_206177.1NP_995899.1NT_033778.3 range: 15343678..15371978
NM_206178.1NP_995900.1NT_033778.3 range: 15343678..15371978
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045172germline ring canalCellular ComponentIDA (11231123)
GO:0045169fusomeCellular ComponentIDA (11231123)
GO:0016323basolateral plasma membraneCellular ComponentIDA (10830165|11231123)
GO:0005938cell cortexCellular ComponentIDA (10830165)
GO:0050321tau-protein kinase activityMolecular FunctionIDA (12874119)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionNAS (10908587)
GO:0004674protein serine/threonine kinase activityMolecular FunctionISS (10830165)
GO:0004672protein kinase activityMolecular FunctionIDA (11951092|14675534)
GO:0016325oocyte microtubule cytoskeleton organizationBiological ProcessIMP (10830165)
GO:0016325oocyte microtubule cytoskeleton organizationBiological ProcessTAS (11700288|11784091|12185850)
GO:0019730antimicrobial humoral responseBiological ProcessIMP (16163390)
GO:0030111regulation of Wnt receptor signaling pathwayBiological ProcessTAS (12517707)
GO:0030707ovarian follicle cell developmentBiological ProcessIMP (15694310)
GO:0000226microtubule cytoskeleton organization and biogenesisBiological ProcessIMP (11231123|12874119)
GO:0045185maintenance of protein localizationBiological ProcessTAS (12517707)
GO:0045451pole plasm oskar mRNA localizationBiological ProcessTAS (11700288)
GO:0009994oocyte differentiationBiological ProcessTAS (11700288)
GO:0009948anterior/posterior axis specificationBiological ProcessTAS (12185850)
GO:0006468protein amino acid phosphorylationBiological ProcessISS (10830165)
GO:0006468protein amino acid phosphorylationBiological ProcessNAS (10908587)
GO:0007015actin filament organizationBiological ProcessIMP (14527345)
GO:0007276gamete generationBiological ProcessIMP
GO:0007294germarium-derived oocyte fate determinationBiological ProcessIMP (11231123|11245586)
GO:0007294germarium-derived oocyte fate determinationBiological ProcessTAS (11784091|12517707)
GO:0007314oocyte anterior/posterior axis determinationBiological ProcessTAS (12517707)
GO:0007317regulation of pole plasm oskar mRNA localizationBiological ProcessIMP (10830165)
GO:0007318pole plasm protein localizationBiological ProcessIMP (10830165|16753562)
GO:0008360regulation of cell shapeBiological ProcessIMP (14527345)
GO:0009798axis specificationBiological ProcessIMP (11231123)
GO:0051663oocyte nucleus localization during oocyte axis determinationBiological ProcessIMP (16753562)
Other Database Cross Links
NCBI Entrez Gene:2768852
FLYBASE:FBgn0026193