ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pycard

Full Name:

PYD and CARD domain containing

Alias:

Asc

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q36

Physical Location:

187276088-187277121 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 29108 Symbol (Name): PYCARD (PYD and CARD domain containing)

Ortholog Status:

The human GeneID 29108 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pycard
Fold Change:		-1.17
P Value:		0.007
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_172322.1	NP_758825.1	NC_005100.2 range: 187276088..187277121, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	ISS
GO:0005622	intracellular	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0042803	protein homodimerization activity	Molecular Function	ISS
GO:0032090	Pyrin domain binding	Molecular Function	ISS
GO:0030693	caspase activity	Molecular Function	IEA
GO:0006954	inflammatory response	Biological Process	ISS
GO:0050718	positive regulation of interleukin-1 beta secretion	Biological Process	ISS
GO:0043281	regulation of caspase activity	Biological Process	ISS
GO:0043280	positive regulation of caspase activity	Biological Process	ISS
GO:0042981	regulation of apoptosis	Biological Process	ISS
GO:0042981	regulation of apoptosis	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	ISS
GO:0006917	induction of apoptosis	Biological Process	IMP (12464617)
GO:0051092	activation of NF-kappaB transcription factor	Biological Process	ISS