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Gene Information
Gene ID:282838
Full Name:GM2 ganglioside activator protein
Organism:Rattus norvegicus (Rat)
Genetic Location:10q22
Physical Location:40502174-40514707 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2760    Symbol (Name): GM2A (GM2 ganglioside activator)
Ortholog Status:The human GeneID 2760 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gm2a
Fold Change:1.13
P Value:0.009
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_172335.2NP_758838.2NC_005109.2 range: 40502174..40514707
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0009898internal side of plasma membraneCellular ComponentIDA (10073593)
GO:0005737cytoplasmCellular ComponentIDA (10073593)
GO:0005739mitochondrionCellular ComponentISS
GO:0005764lysosomeCellular ComponentIDA (8948454)
GO:0005889hydrogen:potassium-exchanging ATPase complexCellular ComponentIDA (10073593)
GO:0045179apical cortexCellular ComponentIDA (10073593)
GO:0016004phospholipase activator activityMolecular FunctionIDA (9770472)
GO:0008289lipid bindingMolecular FunctionIC (8948454)
GO:0032428beta-N-acetylgalactosaminidase activityMolecular FunctionIDA (9770472)
GO:0008047enzyme activator activityMolecular FunctionISS
GO:0005319lipid transporter activityMolecular FunctionIDA (8948454)
GO:0004563beta-N-acetylhexosaminidase activityMolecular FunctionISS
GO:0050877neurological system processBiological ProcessISS
GO:0019915sequestering of lipidBiological ProcessISS
GO:0050885neuromuscular process controlling balanceBiological ProcessISS
GO:0009313oligosaccharide catabolic processBiological ProcessISS
GO:0001573ganglioside metabolic processBiological ProcessIDA (9770472)
GO:0007611learning and/or memoryBiological ProcessISS
GO:0006944membrane fusionBiological ProcessIDA (8948454)
GO:0006869lipid transportBiological ProcessIDA (8948454)
GO:0006689ganglioside catabolic processBiological ProcessISS
GO:0051345positive regulation of hydrolase activityBiological ProcessIDA (9770472)
Other Database Cross Links
NCBI Entrez Gene:282838