ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gm2a

Full Name:

GM2 ganglioside activator protein

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q22

Physical Location:

40502174-40514707 on NC_005109.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2760 Symbol (Name): GM2A (GM2 ganglioside activator)

Ortholog Status:

The human GeneID 2760 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gm2a
Fold Change:		1.13
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_172335.2	NP_758838.2	NC_005109.2 range: 40502174..40514707

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0009898	internal side of plasma membrane	Cellular Component	IDA (10073593)
GO:0005737	cytoplasm	Cellular Component	IDA (10073593)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005764	lysosome	Cellular Component	IDA (8948454)
GO:0005889	hydrogen:potassium-exchanging ATPase complex	Cellular Component	IDA (10073593)
GO:0045179	apical cortex	Cellular Component	IDA (10073593)
GO:0016004	phospholipase activator activity	Molecular Function	IDA (9770472)
GO:0008289	lipid binding	Molecular Function	IC (8948454)
GO:0032428	beta-N-acetylgalactosaminidase activity	Molecular Function	IDA (9770472)
GO:0008047	enzyme activator activity	Molecular Function	ISS
GO:0005319	lipid transporter activity	Molecular Function	IDA (8948454)
GO:0004563	beta-N-acetylhexosaminidase activity	Molecular Function	ISS
GO:0050877	neurological system process	Biological Process	ISS
GO:0019915	sequestering of lipid	Biological Process	ISS
GO:0050885	neuromuscular process controlling balance	Biological Process	ISS
GO:0009313	oligosaccharide catabolic process	Biological Process	ISS
GO:0001573	ganglioside metabolic process	Biological Process	IDA (9770472)
GO:0007611	learning and/or memory	Biological Process	ISS
GO:0006944	membrane fusion	Biological Process	IDA (8948454)
GO:0006869	lipid transport	Biological Process	IDA (8948454)
GO:0006689	ganglioside catabolic process	Biological Process	ISS
GO:0051345	positive regulation of hydrolase activity	Biological Process	IDA (9770472)