ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Unc13c

Full Name:

unc-13 homolog C (C. elegans)

Alias:

Unc13h3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

8q24

Physical Location:

78278727-78703565 on NC_005107.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 440279 Symbol (Name): UNC13C (unc-13 homolog C (C. elegans))

Ortholog Status:

The human GeneID 440279 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Unc13c
Fold Change:		1.19
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_173146.1	NP_775169.2	NC_005107.2 range: 78278727..78703565, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IDA (7559667)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0019992	diacylglycerol binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0007268	synaptic transmission	Biological Process	ISS
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0006887	exocytosis	Biological Process	IEA
GO:0046928	regulation of neurotransmitter secretion	Biological Process	TAS (7559667)