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Gene Information
Gene ID:287367
Full Name:COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)
Organism:Rattus norvegicus (Rat)
Genetic Location:10q22
Physical Location:46139836-46163245 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8533    Symbol (Name): COPS3 (COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis))
Ortholog Status:The human GeneID 8533 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cops3
Fold Change:-1.14
P Value:0.008
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001004200.1NP_001004200.1NC_005109.2 range: 46139836..46163245, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0008180signalosomeCellular ComponentIEA
GO:0008180signalosomeCellular ComponentISS
GO:0005515protein bindingMolecular FunctionISS
GO:0001701in utero embryonic developmentBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:287367