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Gene Information
Gene ID:289076
Full Name:regulator of G-protein signaling 18
Organism:Rattus norvegicus (Rat)
Genetic Location:13q21
Physical Location:58606795-58629596 on NC_005112.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 64407    Symbol (Name): RGS18 (regulator of G-protein signaling 18)
Ortholog Status:The human GeneID 64407 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rgs18
Fold Change:1.35
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_222692.4XP_222692.2NC_005112.2 range: 58606795..58629596, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentISS
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0005096GTPase activator activityMolecular FunctionISS
GO:0016299regulator of G-protein signaling activityMolecular FunctionISS
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessISS
GO:0008277regulation of G-protein coupled receptor protein signaling pathwayBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:289076