ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Id4

Full Name:

inhibitor of DNA binding 4

Alias:

Idb4

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

17p14

Physical Location:

22525291-22527860 on NC_005116.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3400 Symbol (Name): ID4 (inhibitor of DNA binding 4, dominant negative helix-loop-helix protein)

Ortholog Status:

The human GeneID 3400 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Id4
Fold Change:		1.15
P Value:		0.001
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_175582.1	NP_783172.1	NC_005116.2 range: 22525291..22527860, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0030528	transcription regulator activity	Molecular Function	IEA
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	ISS
GO:0045665	negative regulation of neuron differentiation	Biological Process	ISS
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0021895	cerebral cortex neuron differentiation	Biological Process	ISS
GO:0021766	hippocampus development	Biological Process	ISS
GO:0016481	negative regulation of transcription	Biological Process	ISS
GO:0008284	positive regulation of cell proliferation	Biological Process	ISS
GO:0008283	cell proliferation	Biological Process	ISS
GO:0007420	brain development	Biological Process	ISS
GO:0007405	neuroblast proliferation	Biological Process	ISS
GO:0048712	negative regulation of astrocyte differentiation	Biological Process	ISS