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Gene Information
Gene ID:291023
Full Name:inhibitor of DNA binding 4
Organism:Rattus norvegicus (Rat)
Genetic Location:17p14
Physical Location:22525291-22527860 on NC_005116.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3400    Symbol (Name): ID4 (inhibitor of DNA binding 4, dominant negative helix-loop-helix protein)
Ortholog Status:The human GeneID 3400 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Id4
Fold Change:1.15
P Value:0.001
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_175582.1NP_783172.1NC_005116.2 range: 22525291..22527860, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0030528transcription regulator activityMolecular FunctionIEA
GO:0000082G1/S transition of mitotic cell cycleBiological ProcessISS
GO:0045665negative regulation of neuron differentiationBiological ProcessISS
GO:0045449regulation of transcriptionBiological ProcessIEA
GO:0021895cerebral cortex neuron differentiationBiological ProcessISS
GO:0021766hippocampus developmentBiological ProcessISS
GO:0016481negative regulation of transcriptionBiological ProcessISS
GO:0008284positive regulation of cell proliferationBiological ProcessISS
GO:0008283cell proliferationBiological ProcessISS
GO:0007420brain developmentBiological ProcessISS
GO:0007405neuroblast proliferationBiological ProcessISS
GO:0048712negative regulation of astrocyte differentiationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:291023