ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dcn

Full Name:

decorin

Alias:

MGC94682

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q13

Physical Location:

35004233-35045190 on NC_005106.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1634 Symbol (Name): DCN (decorin)

Ortholog Status:

The human GeneID 1634 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.3819
Original ID2:		Dcn
Fold Change:		2.07
P Value:		0.00007
Note:		higher levels in hippocampus of iP than iNP rats

Gene Information

Original ID1:		Rn.3819
Original ID2:		Dcn
Fold Change:		1.71
P Value:		0.00225
Note:		higher levels in hippocampus of iP than iNP rats

Gene Information

Original ID1:		Rn.3819
Original ID2:		Dcn
Fold Change:		1.8
P Value:		0.00367
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024129.1	NP_077043.1	NC_005106.2 range: 35004233..35045190

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IDA (12840020)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005518	collagen binding	Molecular Function	IDA (12840020)
GO:0047485	protein N-terminus binding	Molecular Function	IDA (12840020)
GO:0030198	extracellular matrix organization and biogenesis	Biological Process	IPI (12840020)