ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Syn2

Full Name:

synapsin II

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q42

Physical Location:

151255240-151413219 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6854 Symbol (Name): SYN2 (synapsin II)

Ortholog Status:

The human GeneID 6854 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.506
Original ID2:		Syn2
Fold Change:		1.21
P Value:		0.00897
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008021	synaptic vesicle	Cellular Component	TAS (2506642)
GO:0030672	synaptic vesicle membrane	Cellular Component	ISS
GO:0045202	synapse	Cellular Component	ISS
GO:0008092	cytoskeletal protein binding	Molecular Function	TAS (2506642)
GO:0007269	neurotransmitter secretion	Biological Process	ISS
GO:0046928	regulation of neurotransmitter secretion	Biological Process	TAS (2506642)