Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:292156
Symbol:Sh3glb1
Full Name:SH3-domain GRB2-like B1 (endophilin)
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q44
Physical Location:242874677-242903466 on NC_005101.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 51100    Symbol (Name): SH3GLB1 (SH3-domain GRB2-like endophilin B1)
Ortholog Status:The human GeneID 51100 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Sh3glb1
Fold Change:1.16
P Value:0.008
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001011929.1NP_001011929.1NC_005101.2 range: 242874677..242903466, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000139Golgi membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentISS
GO:0019867outer membraneCellular ComponentIEA
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0005792microsomeCellular ComponentISS
GO:0005741mitochondrial outer membraneCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0042171lysophosphatidic acid acyltransferase activityMolecular FunctionISS
GO:0005504fatty acid bindingMolecular FunctionISS
GO:0042803protein homodimerization activityMolecular FunctionISS
GO:0008289lipid bindingMolecular FunctionIEA
GO:0008654phospholipid biosynthetic processBiological ProcessISS
GO:0006916anti-apoptosisBiological ProcessISS
GO:0006915apoptosisBiological ProcessIEA
GO:0006654phosphatidic acid biosynthetic processBiological ProcessISS
GO:0001844protein insertion into mitochondrial membrane during induction of apoptosisBiological ProcessISS
GO:0051084'de novo' posttranslational protein foldingBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:292156
RGD:1304859
Ensembl:ENSRNOG00000012957
dbSNP:Sh3glb1