ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nfib

Full Name:

nuclear factor I/B

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q31

Physical Location:

101178442-101615789 on NC_005104.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4781 Symbol (Name): NFIB (nuclear factor I/B)

Ortholog Status:

The human GeneID 4781 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nfib
Fold Change:		1.12
P Value:		0.009
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Nfib
Fold Change:		1.15
P Value:		0.005
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Nfib
Fold Change:		1.15
P Value:		0.01
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0003690	double-stranded DNA binding	Molecular Function	IDA (10521600)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IPI (10521600)
GO:0030902	hindbrain development	Biological Process	ISS
GO:0030900	forebrain development	Biological Process	ISS
GO:0030324	lung development	Biological Process	ISS
GO:0016481	negative regulation of transcription	Biological Process	TAS (10521600)
GO:0008285	negative regulation of cell proliferation	Biological Process	ISS
GO:0007608	sensory perception of smell	Biological Process	NAS (10521600)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006260	DNA replication	Biological Process	IEA
GO:0045941	positive regulation of transcription	Biological Process	TAS (10521600)