ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

29290

Symbol:

Adora1

Full Name:

adenosine A1 receptor

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q13

Physical Location:

47159041-47193162 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 134 Symbol (Name): ADORA1 (adenosine A1 receptor)

Ortholog Status:

The human GeneID 134 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		29290
Fold Change:		1.454
P Value:		0.008
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017155.2	NP_058851.2	NC_005112.2 range: 47159041..47193162, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042734	presynaptic membrane	Cellular Component	IDA (16481441)
GO:0012505	endomembrane system	Cellular Component	IDA (16952160)
GO:0014069	postsynaptic density	Cellular Component	IDA (14499945)
GO:0048786	presynaptic active zone	Cellular Component	IDA (16481441)
GO:0005886	plasma membrane	Cellular Component	IDA (12153486\|16952160)
GO:0005783	endoplasmic reticulum	Cellular Component	IMP (12764156)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016323	basolateral plasma membrane	Cellular Component	IDA (15024061)
GO:0030425	dendrite	Cellular Component	IDA (16952160)
GO:0030673	axolemma	Cellular Component	IDA (16481441)
GO:0045211	postsynaptic membrane	Cellular Component	IDA (16481441)
GO:0043195	terminal button	Cellular Component	IDA (16952160)
GO:0032279	asymmetric synapse	Cellular Component	IDA (16481441)
GO:0043025	cell soma	Cellular Component	IDA (15044554)
GO:0032795	heterotrimeric G-protein binding	Molecular Function	IDA (12764156)
GO:0001883	purine nucleoside binding	Molecular Function	IPI (11906959)
GO:0031683	G-protein beta/gamma-subunit binding	Molecular Function	IDA (12764156)
GO:0046982	protein heterodimerization activity	Molecular Function	IPI (16481441)
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0001609	adenosine receptor activity, G-protein coupled	Molecular Function	IDA (9261808)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0001609	adenosine receptor activity, G-protein coupled	Molecular Function	IEA
GO:0001609	adenosine receptor activity, G-protein coupled	Molecular Function	TAS (12153486)
GO:0043066	negative regulation of apoptosis	Biological Process	IDA (12578815)
GO:0043268	positive regulation of potassium ion transport	Biological Process	IDA (9261808)
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process	ISS
GO:0046888	negative regulation of hormone secretion	Biological Process	IMP (15044554)
GO:0051967	negative regulation of synaptic transmission, glutamatergic	Biological Process	IDA (16481441)
GO:0045777	positive regulation of blood pressure	Biological Process	IDA (12234813)
GO:0050995	negative regulation of lipid catabolic process	Biological Process	IDA (15220221)
GO:0048167	regulation of synaptic plasticity	Biological Process	IMP (14596853)
GO:0045822	negative regulation of heart contraction	Biological Process	IMP (16286581)
GO:0045908	negative regulation of vasodilation	Biological Process	IDA (12100087)
GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	Biological Process	IDA
GO:0042312	regulation of vasodilation	Biological Process	IDA (12100087)
GO:0002087	neurological control of breathing	Biological Process	IMP (16352472)
GO:0002793	positive regulation of peptide secretion	Biological Process	IMP (16286581)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IDA (12764156)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	Biological Process	IMP (16286581)
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA (12021208)
GO:0014050	negative regulation of glutamate secretion	Biological Process	IDA (16481441)
GO:0030147	natriuresis	Biological Process	IMP (14993484)
GO:0000186	activation of MAPKK activity	Biological Process	IDA (12764156)
GO:0032229	negative regulation of synaptic transmission, GABAergic	Biological Process	IDA (12626609)
GO:0032229	negative regulation of synaptic transmission, GABAergic	Biological Process	IMP (12626609)
GO:0032244	positive regulation of nucleoside transport	Biological Process	IDA (15024061)
GO:0035307	positive regulation of protein amino acid dephosphorylation	Biological Process	IDA (12234781)
GO:0001659	temperature homeostasis	Biological Process	IMP (16352472)