ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gpx4

Full Name:

glutathione peroxidase 4

Alias:

Phgpx|gpx-4|snGpx

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q11

Physical Location:

11162520-11165317 on NC_005106.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2879 Symbol (Name): GPX4 (glutathione peroxidase 4 (phospholipid hydroperoxidase))

Ortholog Status:

The human GeneID 2879 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gpx4
Fold Change:		1.15
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017165.2	NP_058861.3	NC_005106.2 range: 11162520..11165317, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005625	soluble fraction	Cellular Component	IDA (16140890)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005635	nuclear envelope	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	ISS
GO:0005743	mitochondrial inner membrane	Cellular Component	ISS
GO:0008430	selenium binding	Molecular Function	IDA (8749327)
GO:0004602	glutathione peroxidase activity	Molecular Function	IDA (16140890)
GO:0008430	selenium binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0043295	glutathione binding	Molecular Function	IDA (16140890)
GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	Molecular Function	IDA (8749327)
GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	Molecular Function	IEA
GO:0004602	glutathione peroxidase activity	Molecular Function	ISS
GO:0008430	selenium binding	Molecular Function	IMP (16140890)
GO:0042744	hydrogen peroxide catabolic process	Biological Process	IDA (16140890)
GO:0007283	spermatogenesis	Biological Process	ISS
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0006979	response to oxidative stress	Biological Process	IEA
GO:0006749	glutathione metabolic process	Biological Process	IDA (16140890)
GO:0006325	establishment and/or maintenance of chromatin architecture	Biological Process	ISS
GO:0050727	regulation of inflammatory response	Biological Process	IMP (12397078)