ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hs3st2

Full Name:

heparan sulfate (glucosamine) 3-O-sulfotransferase 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q36

Physical Location:

180202790-180324717 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9956 Symbol (Name): HS3ST2 (heparan sulfate (glucosamine) 3-O-sulfotransferase 2)

Ortholog Status:

The human GeneID 9956 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs3st2
Fold Change:		1.27
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_181370.2	NP_852035.1	NC_005100.2 range: 180202790..180324717

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0008467	heparin-glucosamine 3-O-sulfotransferase activity	Molecular Function	TAS (12601002)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0033871	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity	Molecular Function	IEA
GO:0007623	circadian rhythm	Biological Process	IDA (12601002)