ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tef

Full Name:

thyrotroph embryonic factor

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q34

Physical Location:

120164880-120179983 on NC_005106.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7008 Symbol (Name): TEF (thyrotrophic embryonic factor)

Ortholog Status:

The human GeneID 7008 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Tef
Fold Change:		-1.2
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Tef
Fold Change:		-1.2
P Value:		0.006
Note:		Differential expression between ethanol and water groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019194.2	NP_062067.2	NC_005106.2 range: 120164880..120179983

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEP (1916262)
GO:0005634	nucleus	Cellular Component	IEA
GO:0016563	transcription activator activity	Molecular Function	ISS
GO:0016563	transcription activator activity	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0003690	double-stranded DNA binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003690	double-stranded DNA binding	Molecular Function	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0048511	rhythmic process	Biological Process	IEA