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Gene Information
Gene ID:29419
Symbol:Numb
Full Name:numb gene homolog (Drosophila)
Alias:MGC188364
Organism:Rattus norvegicus (Rat)
Chromosome:6
Genetic Location:6q31
Physical Location:107838215-107882301 on NC_005105.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8650    Symbol (Name): NUMB (numb homolog (Drosophila))
Ortholog Status:The human GeneID 8650 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Numb
Fold Change:1.18
P Value:0.002
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_133287.1NP_579821.1NC_005105.2 range: 107838215..107882301, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045177apical part of cellCellular ComponentISS
GO:0005634nucleusCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005769early endosomeCellular ComponentISS
GO:0019897extrinsic to plasma membraneCellular ComponentISS
GO:0005515protein bindingMolecular FunctionISS
GO:0007405neuroblast proliferationBiological ProcessISS
GO:0008283cell proliferationBiological ProcessNAS (12500307)
GO:0007399nervous system developmentBiological ProcessISS
GO:0030154cell differentiationBiological ProcessNAS (12500307)
GO:0030900forebrain developmentBiological ProcessISS
GO:0007409axonogenesisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:29419
RGD:620107
Ensembl:ENSRNOG00000009653
dbSNP:Numb