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Gene Information
Gene ID:29432
Symbol:Pak2
Full Name:p21 (CDKN1A)-activated kinase 2
Alias:gamma-PAK
Organism:Rattus norvegicus (Rat)
Chromosome:11
Genetic Location:11q22
Physical Location:70529960-70588514 on NC_005110.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5062    Symbol (Name): PAK2 (p21 (CDKN1A)-activated kinase 2)
Ortholog Status:The human GeneID 5062 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pak2
Fold Change:-1.2
Tissue:Amygdala
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053306.2NP_445758.2NC_005110.2 range: 70529960..70588514
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0042802identical protein bindingMolecular FunctionISS
GO:0042802identical protein bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionISS
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0046777protein amino acid autophosphorylationBiological ProcessIEA
GO:0046777protein amino acid autophosphorylationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:29432
RGD:61953
Ensembl:ENSRNOG00000001747
dbSNP:Pak2