ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pak2

Full Name:

p21 (CDKN1A)-activated kinase 2

Alias:

gamma-PAK

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

11q22

Physical Location:

70529960-70588514 on NC_005110.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5062 Symbol (Name): PAK2 (p21 (CDKN1A)-activated kinase 2)

Ortholog Status:

The human GeneID 5062 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053306.2	NP_445758.2	NC_005110.2 range: 70529960..70588514

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0042802	identical protein binding	Molecular Function	ISS
GO:0042802	identical protein binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	ISS
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0046777	protein amino acid autophosphorylation	Biological Process	IEA
GO:0046777	protein amino acid autophosphorylation	Biological Process	ISS