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Gene Information
Gene ID:29441
Full Name:P450 (cytochrome) oxidoreductase
Organism:Rattus norvegicus (Rat)
Genetic Location:12q12
Physical Location:22078628-22097531 on NC_005111.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5447    Symbol (Name): POR (P450 (cytochrome) oxidoreductase)
Ortholog Status:The human GeneID 5447 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Por
Fold Change:1.11
P Value:0.01
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031576.1NP_113764.1NC_005111.2 range: 22078628..22097531, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005792microsomeCellular ComponentIEA
GO:0005792microsomeCellular ComponentISS
GO:0005792microsomeCellular ComponentIDA (9774150)
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIDA (9774150)
GO:0005625soluble fractionCellular ComponentISS
GO:0005625soluble fractionCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0019899enzyme bindingMolecular FunctionIMP (16928691)
GO:0050660FAD bindingMolecular FunctionIMP (16928691)
GO:0019899enzyme bindingMolecular FunctionIDA (9774150)
GO:0050661NADP bindingMolecular FunctionIDA (9774150)
GO:0016491oxidoreductase activityMolecular FunctionISS
GO:0010181FMN bindingMolecular FunctionIMP (16928691)
GO:0010181FMN bindingMolecular FunctionIEA
GO:0003958NADPH-hemoprotein reductase activityMolecular FunctionIDA (9774150)
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0003958NADPH-hemoprotein reductase activityMolecular FunctionIMP (16928691)
GO:0003958NADPH-hemoprotein reductase activityMolecular FunctionIEA
GO:0050661NADP bindingMolecular FunctionIMP (16928691)
Other Database Cross Links
NCBI Entrez Gene:29441