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Gene Information
Gene ID:29458
Symbol:Neurod1
Full Name:neurogenic differentiation 1
Organism:Rattus norvegicus (Rat)
Chromosome:3
Physical Location:62224619-62227935 on NC_005102.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4760    Symbol (Name): NEUROD1 (neurogenic differentiation 1)
Ortholog Status:The human GeneID 4760 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Neurod1
Fold Change:-1.15
P Value:0.008
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019218.2NP_062091.1NC_005102.2 range: 62224619..62227935, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0003677DNA bindingMolecular FunctionIEA
GO:0043565sequence-specific DNA bindingMolecular FunctionISS
GO:0030528transcription regulator activityMolecular FunctionIEA
GO:0016563transcription activator activityMolecular FunctionISS
GO:0008134transcription factor bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0003677DNA bindingMolecular FunctionISS
GO:0003690double-stranded DNA bindingMolecular FunctionIDA (10101232)
GO:0046982protein heterodimerization activityMolecular FunctionISS
GO:0003700transcription factor activityMolecular FunctionISS
GO:0003702RNA polymerase II transcription factor activityMolecular FunctionISS
GO:0007399nervous system developmentBiological ProcessIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0045666positive regulation of neuron differentiationBiological ProcessIDA (10101232)
GO:0045165cell fate commitmentBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0043010camera-type eye developmentBiological ProcessISS
GO:0042493response to drugBiological ProcessIEP (16417573)
GO:0030902hindbrain developmentBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessISS
GO:0030154cell differentiationBiological ProcessIEA
GO:0007263nitric oxide mediated signal transductionBiological ProcessISS
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0009952anterior/posterior pattern formationBiological ProcessISS
GO:0009749response to glucose stimulusBiological ProcessISS
GO:0021549cerebellum developmentBiological ProcessIEP (12242038)
Other Database Cross Links
NCBI Entrez Gene:29458
RGD:3165
Ensembl:ENSRNOG00000005609
dbSNP:Neurod1