| Gene Information |
| Gene ID: | | 2949 |
| Symbol: | | GSTM5 |
| Full Name: | | glutathione S-transferase M5 |
| Alias: | | GSTM5-5|GTM5 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 1 |
| Genetic Location: | | 1p13.3 |
| Physical Location: | | 110056387-110062410 on NC_000001.9 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AI797367 | | Fold Change: | | -1.4, -1.7 | | Note: | | Differential Expression on the cDNA array (two fold changes are from two case groups) |
| | Dataset Information | | Name: | | 11141048 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed | | Summary: | | RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics. |
| | Gene Information | | Original ID1: | | L02321 | | Fold Change: | | 2.35 |
| | Dataset Information | | Name: | | 15236863 | | Method: | | Microarray | | Tissue: | | Prefrontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed | | Summary: | | We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005737 | cytoplasm | Cellular Component | IEA | |
| GO:0004364 | glutathione transferase activity | Molecular Function | IEA | |
| GO:0004364 | glutathione transferase activity | Molecular Function | TAS (8473333) | |
| GO:0016740 | transferase activity | Molecular Function | IEA | |
| GO:0008152 | metabolic process | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 2949 |
| HGNC: | | 4637 |
| Ensembl: | | ENSG00000134201 |
| MIM: | | 138385 |
| HPRD: | | 00711 |
| HuGE Navigator: | | 2949 |
| dbSNP: | | GSTM5 |
| GeneCard: | | GSTM5 |
| AceView: | | GSTM5 |
