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Gene Information
Gene ID:2949
Symbol:GSTM5
Full Name:glutathione S-transferase M5
Alias:GSTM5-5|GTM5
Organism:Homo sapiens (Human)
Chromosome:1
Genetic Location:1p13.3
Physical Location:110056387-110062410 on NC_000001.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI797367
Fold Change:-1.4, -1.7
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:L02321
Fold Change:2.35
Dataset Information
Name:15236863
Method:Microarray
Tissue:Prefrontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000851.2NP_000842.2NC_000001.9 range: 110056387..110062410
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0004364glutathione transferase activityMolecular FunctionIEA
GO:0004364glutathione transferase activityMolecular FunctionTAS (8473333)
GO:0016740transferase activityMolecular FunctionIEA
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:2949
HGNC:4637
Ensembl:ENSG00000134201
MIM:138385
HPRD:00711
HuGE Navigator:2949
dbSNP:GSTM5
GeneCard:GSTM5
AceView:GSTM5