ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pctp

Full Name:

phosphatidylcholine transfer protein

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q26

Physical Location:

78400327-78420773 on NC_005109.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 58488 Symbol (Name): PCTP (phosphatidylcholine transfer protein)

Ortholog Status:

The human GeneID 58488 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pctp
Fold Change:		-1.14
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017225.1	NP_058921.1	NC_005109.2 range: 78400327..78420773, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	TAS (10415339)
GO:0008289	lipid binding	Molecular Function	IEA
GO:0008525	phosphatidylcholine transmembrane transporter activity	Molecular Function	TAS (10415339)
GO:0006869	lipid transport	Biological Process	IEA
GO:0008203	cholesterol metabolic process	Biological Process	IEA
GO:0008203	cholesterol metabolic process	Biological Process	ISS
GO:0015914	phospholipid transport	Biological Process	TAS (10415339)