ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

29517

Symbol:

Sgk1

Full Name:

serum/glucocorticoid regulated kinase 1

Alias:

Sgk

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1p12

Physical Location:

23501261-23506701 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6446 Symbol (Name): SGK1 (serum/glucocorticoid regulated kinase 1)

Ortholog Status:

The human GeneID 6446 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Sgk
Fold Change:		1.29
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019232.2	NP_062105.2	NC_005100.2 range: 23501261..23506701, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (10066787\|10357815)
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA (10066787)
GO:0043005	neuron projection	Cellular Component	IDA (16982696)
GO:0005737	cytoplasm	Cellular Component	IDA (10357815)
GO:0043423	3-phosphoinositide-dependent protein kinase binding	Molecular Function	IPI (10357815)
GO:0048156	tau protein binding	Molecular Function	IPI (16982696)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS (11250940)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (16982696)
GO:0004672	protein kinase activity	Molecular Function	ISS
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (15795328)
GO:0043402	glucocorticoid mediated signaling	Biological Process	IMP (16982696)
GO:0048812	neurite morphogenesis	Biological Process	IDA (16982696)
GO:0050775	positive regulation of dendrite morphogenesis	Biological Process	IMP (16049181)
GO:0031115	negative regulation of microtubule polymerization	Biological Process	IDA (16982696)
GO:0030307	positive regulation of cell growth	Biological Process	IDA (15795328)
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (11250940)
GO:0006883	cellular sodium ion homeostasis	Biological Process	IDA (11250940)
GO:0006974	response to DNA damage stimulus	Biological Process	ISS
GO:0007019	microtubule depolymerization	Biological Process	IDA (16982696)
GO:0007616	long-term memory	Biological Process	IMP (11891330)
GO:0008542	visual learning	Biological Process	IMP (14656333)
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA (16982696)
GO:0051726	regulation of cell cycle	Biological Process	IMP (10066787)