Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:295214
Symbol:S100a1
Full Name:S100 calcium binding protein A1
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q34
Physical Location:182784662-182789415 on NC_005101.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6271    Symbol (Name): S100A1 (S100 calcium binding protein A1)
Ortholog Status:The human GeneID 6271 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:S100a1
Fold Change:1.1
P Value:0.006
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001007636.1NP_001007637.1NC_005101.2 range: 182784662..182789415, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016529sarcoplasmic reticulumCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIEA
GO:0005829cytosolCellular ComponentTAS (16129693)
GO:0048155S100 alpha bindingMolecular FunctionISS
GO:0048154S100 beta bindingMolecular FunctionISS
GO:0042803protein homodimerization activityMolecular FunctionNAS (12619862)
GO:0042803protein homodimerization activityMolecular FunctionISS
GO:0042802identical protein bindingMolecular FunctionISS
GO:0051117ATPase bindingMolecular FunctionISS
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionTAS (12619862)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIMP (12619862)
Other Database Cross Links
NCBI Entrez Gene:295214
RGD:3614
Ensembl:ENSRNOG00000012410
dbSNP:S100a1