ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

S100a1

Full Name:

S100 calcium binding protein A1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q34

Physical Location:

182784662-182789415 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6271 Symbol (Name): S100A1 (S100 calcium binding protein A1)

Ortholog Status:

The human GeneID 6271 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		S100a1
Fold Change:		1.1
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001007636.1	NP_001007637.1	NC_005101.2 range: 182784662..182789415, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016529	sarcoplasmic reticulum	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	TAS (16129693)
GO:0048155	S100 alpha binding	Molecular Function	ISS
GO:0048154	S100 beta binding	Molecular Function	ISS
GO:0042803	protein homodimerization activity	Molecular Function	NAS (12619862)
GO:0042803	protein homodimerization activity	Molecular Function	ISS
GO:0042802	identical protein binding	Molecular Function	ISS
GO:0051117	ATPase binding	Molecular Function	ISS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	TAS (12619862)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IMP (12619862)