ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Homer1

Full Name:

homer homolog 1 (Drosophila)

Alias:

HOMER1F|Vesl-1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q12

Physical Location:

23581442-23624107 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9456 Symbol (Name): HOMER1 (homer homolog 1 (Drosophila))

Ortholog Status:

The human GeneID 9456 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Homer1
Fold Change:		1.75
P Value:		0.005
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Homer1
Fold Change:		3.49
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Homer1
Fold Change:		2.19
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_001068911.1	XP_001068911.1	NC_005101.2 range: 23581442..23624107

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0030425	dendrite	Cellular Component	IDA (16554037)
GO:0043025	cell soma	Cellular Component	IDA (16554037)
GO:0005102	receptor binding	Molecular Function	IDA (9069287)
GO:0005515	protein binding	Molecular Function	ISS
GO:0031802	type 5 metabotropic glutamate receptor binding	Molecular Function	IPI (16554037)
GO:0007216	metabotropic glutamate receptor signaling pathway	Biological Process	IPI (9069287)