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Gene Information
Gene ID:29546
Symbol:Homer1
Full Name:homer homolog 1 (Drosophila)
Alias:HOMER1F|Vesl-1
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q12
Physical Location:23581442-23624107 on NC_005101.2
Gene Type:protein-coding
Human Ortholog:GeneID: 9456    Symbol (Name): HOMER1 (homer homolog 1 (Drosophila))
Ortholog Status:The human GeneID 9456 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Homer1
Fold Change:1.75
P Value:0.005
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Homer1
Fold Change:3.49
P Value:0
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Homer1
Fold Change:2.19
P Value:0
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_001068911.1XP_001068911.1NC_005101.2 range: 23581442..23624107
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005624membrane fractionCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005886plasma membraneCellular ComponentISS
GO:0030425dendriteCellular ComponentIDA (16554037)
GO:0043025cell somaCellular ComponentIDA (16554037)
GO:0005102receptor bindingMolecular FunctionIDA (9069287)
GO:0005515protein bindingMolecular FunctionISS
GO:0031802type 5 metabotropic glutamate receptor bindingMolecular FunctionIPI (16554037)
GO:0007216metabotropic glutamate receptor signaling pathwayBiological ProcessIPI (9069287)
Other Database Cross Links
NCBI Entrez Gene:29546
RGD:628725
Ensembl:
dbSNP:Homer1