ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Homer2

Full Name:

homer homolog 2 (Drosophila)

Alias:

Vesl-2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q31

Physical Location:

137827127-137933088 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9455 Symbol (Name): HOMER2 (homer homolog 2 (Drosophila))

Ortholog Status:

The human GeneID 9455 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Homer2
Fold Change:		-1.16
P Value:		0.008
Note:		Differential expression between ethanol and water groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053309.1	NP_445761.1	NC_005100.2 range: 137827127..137933088, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0003779	actin binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0030160	GKAP/Homer scaffold activity	Molecular Function	ISS