ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hes1

Full Name:

hairy and enhancer of split 1 (Drosophila)

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

11q22

Physical Location:

72603850-72606211 on NC_005110.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3280 Symbol (Name): HES1 (hairy and enhancer of split 1, (Drosophila))

Ortholog Status:

The human GeneID 3280 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hes1
Fold Change:		1.19
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024360.3	NP_077336.3	NC_005110.2 range: 72603850..72606211, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0016564	transcription repressor activity	Molecular Function	TAS (12478609)
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0030528	transcription regulator activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	ISS
GO:0003677	DNA binding	Molecular Function	IEA
GO:0045608	negative regulation of auditory receptor cell differentiation	Biological Process	ISS
GO:0045596	negative regulation of cell differentiation	Biological Process	ISS
GO:0048469	cell maturation	Biological Process	ISS
GO:0045165	cell fate commitment	Biological Process	ISS
GO:0042668	auditory receptor cell fate determination	Biological Process	ISS
GO:0042491	auditory receptor cell differentiation	Biological Process	ISS
GO:0045665	negative regulation of neuron differentiation	Biological Process	ISS
GO:0030324	lung development	Biological Process	ISS
GO:0021983	pituitary gland development	Biological Process	ISS
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0008284	positive regulation of cell proliferation	Biological Process	ISS
GO:0007155	cell adhesion	Biological Process	ISS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0001889	liver development	Biological Process	ISS
GO:0048505	regulation of timing of cell differentiation	Biological Process	ISS