ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

29595

Symbol:

Htr2a

Full Name:

5-hydroxytryptamine (serotonin) receptor 2A

Alias:

5Ht-2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

15q11

Physical Location:

55463742-55532292 on NC_005114.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3356 Symbol (Name): HTR2A (5-hydroxytryptamine (serotonin) receptor 2A)

Ortholog Status:

The human GeneID 3356 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Htr2a
Fold Change:		-1.27
P Value:		0.007
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017254.1	NP_058950.1	NC_005114.2 range: 55463742..55532292

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0030425	dendrite	Cellular Component	IDA (10524335)
GO:0005737	cytoplasm	Cellular Component	IDA (10379914)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0032403	protein complex binding	Molecular Function	IPI (16527989)
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0043406	positive regulation of MAP kinase activity	Biological Process	IMP (15087293)
GO:0042493	response to drug	Biological Process	IMP (17077317)
GO:0030431	sleep	Biological Process	IMP (17059817)
GO:0045907	positive regulation of vasoconstriction	Biological Process	IMP (16527989)
GO:0019233	sensory perception of pain	Biological Process	IMP (16527395)
GO:0043267	negative regulation of potassium ion transport	Biological Process	IMP (16527989)
GO:0014059	regulation of dopamine secretion	Biological Process	IMP (15999145)
GO:0008284	positive regulation of cell proliferation	Biological Process	IMP (15087293)
GO:0001659	temperature homeostasis	Biological Process	IMP (17067560)
GO:0006950	response to stress	Biological Process	IMP (15999145)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007208	serotonin receptor, phospholipase C activating pathway	Biological Process	IDA (17010161)
GO:0007568	aging	Biological Process	IEP (17374516)
GO:0007613	memory	Biological Process	IMP (16149040)
GO:0008219	cell death	Biological Process	IMP (16504407)
GO:0051967	negative regulation of synaptic transmission, glutamatergic	Biological Process	IMP (17016851)