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Gene Information
Gene ID:29595
Full Name:5-hydroxytryptamine (serotonin) receptor 2A
Organism:Rattus norvegicus (Rat)
Genetic Location:15q11
Physical Location:55463742-55532292 on NC_005114.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3356    Symbol (Name): HTR2A (5-hydroxytryptamine (serotonin) receptor 2A)
Ortholog Status:The human GeneID 3356 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Htr2a
Fold Change:-1.27
P Value:0.007
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017254.1NP_058950.1NC_005114.2 range: 55463742..55532292
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0030425dendriteCellular ComponentIDA (10524335)
GO:0005737cytoplasmCellular ComponentIDA (10379914)
GO:0005886plasma membraneCellular ComponentIEA
GO:0032403protein complex bindingMolecular FunctionIPI (16527989)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0043406positive regulation of MAP kinase activityBiological ProcessIMP (15087293)
GO:0042493response to drugBiological ProcessIMP (17077317)
GO:0030431sleepBiological ProcessIMP (17059817)
GO:0045907positive regulation of vasoconstrictionBiological ProcessIMP (16527989)
GO:0019233sensory perception of painBiological ProcessIMP (16527395)
GO:0043267negative regulation of potassium ion transportBiological ProcessIMP (16527989)
GO:0014059regulation of dopamine secretionBiological ProcessIMP (15999145)
GO:0008284positive regulation of cell proliferationBiological ProcessIMP (15087293)
GO:0001659temperature homeostasisBiological ProcessIMP (17067560)
GO:0006950response to stressBiological ProcessIMP (15999145)
GO:0007165signal transductionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007208serotonin receptor, phospholipase C activating pathwayBiological ProcessIDA (17010161)
GO:0007568agingBiological ProcessIEP (17374516)
GO:0007613memoryBiological ProcessIMP (16149040)
GO:0008219cell deathBiological ProcessIMP (16504407)
GO:0051967negative regulation of synaptic transmission, glutamatergicBiological ProcessIMP (17016851)
Other Database Cross Links
NCBI Entrez Gene:29595