ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Atp2b4

Full Name:

ATPase, Ca++ transporting, plasma membrane 4

Alias:

PMCA4

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q13

Physical Location:

46631204-46697213 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 493 Symbol (Name): ATP2B4 (ATPase, Ca++ transporting, plasma membrane 4)

Ortholog Status:

The human GeneID 493 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Atp2b4
Fold Change:		-1.27
P Value:		0.001
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Atp2b4
Fold Change:		-1.25
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001005871.1	NP_001005871.1	NC_005112.2 range: 46631204..46697213, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (11779484)
GO:0005388	calcium-transporting ATPase activity	Molecular Function	IDA (11779484)
GO:0030165	PDZ domain binding	Molecular Function	IPI (16554037)
GO:0030165	PDZ domain binding	Molecular Function	TAS (12511555)
GO:0006816	calcium ion transport	Biological Process	IDA (11779484)
GO:0006874	cellular calcium ion homeostasis	Biological Process	TAS (12511555)
GO:0019722	calcium-mediated signaling	Biological Process	TAS (12511555)