ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Bckdk

Full Name:

branched chain ketoacid dehydrogenase kinase

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q36

Physical Location:

187190380-187194917 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10295 Symbol (Name): BCKDK (branched chain ketoacid dehydrogenase kinase)

Ortholog Status:

The human GeneID 10295 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Bckdk
Fold Change:		1.16
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019244.2	NP_062117.2	NC_005100.2 range: 187190380..187194917

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	Cellular Component	IDA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005739	mitochondrion	Cellular Component	TAS (11562470)
GO:0005759	mitochondrial matrix	Cellular Component	IEA
GO:0047323	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	Molecular Function	IMP (1377677\|7649998)
GO:0047323	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000155	two-component sensor activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA
GO:0004672	protein kinase activity	Molecular Function	ISS
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA
GO:0047323	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	Molecular Function	TAS (11562470)
GO:0005515	protein binding	Molecular Function	ISS
GO:0009083	branched chain family amino acid catabolic process	Biological Process	TAS (11562470)
GO:0018106	peptidyl-histidine phosphorylation	Biological Process	IEA
GO:0009083	branched chain family amino acid catabolic process	Biological Process	IDA
GO:0007165	signal transduction	Biological Process	IEA
GO:0016310	phosphorylation	Biological Process	IDA