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Gene Information
Gene ID:29603
Symbol:Bckdk
Full Name:branched chain ketoacid dehydrogenase kinase
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q36
Physical Location:187190380-187194917 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 10295    Symbol (Name): BCKDK (branched chain ketoacid dehydrogenase kinase)
Ortholog Status:The human GeneID 10295 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Bckdk
Fold Change:1.16
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019244.2NP_062117.2NC_005100.2 range: 187190380..187194917
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005947mitochondrial alpha-ketoglutarate dehydrogenase complexCellular ComponentIDA
GO:0005739mitochondrionCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentISS
GO:0005739mitochondrionCellular ComponentTAS (11562470)
GO:0005759mitochondrial matrixCellular ComponentIEA
GO:0047323[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activityMolecular FunctionIMP (1377677|7649998)
GO:0047323[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0000155two-component sensor activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIDA
GO:0004672protein kinase activityMolecular FunctionISS
GO:0004674protein serine/threonine kinase activityMolecular FunctionIDA
GO:0047323[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activityMolecular FunctionTAS (11562470)
GO:0005515protein bindingMolecular FunctionISS
GO:0009083branched chain family amino acid catabolic processBiological ProcessTAS (11562470)
GO:0018106peptidyl-histidine phosphorylationBiological ProcessIEA
GO:0009083branched chain family amino acid catabolic processBiological ProcessIDA
GO:0007165signal transductionBiological ProcessIEA
GO:0016310phosphorylationBiological ProcessIDA
Other Database Cross Links
NCBI Entrez Gene:29603
RGD:2198
Ensembl:ENSRNOG00000019485
dbSNP:Bckdk