ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gria3

Full Name:

glutamate receptor, ionotropic, AMPA3 (alpha 3)

Alias:

GLUR3|GluR-3|GluR-C|GluR-K3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

Xq11

Physical Location:

3454528-3718485 on NC_005120.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2892 Symbol (Name): GRIA3 (glutamate receptor, ionotrophic, AMPA 3)

Ortholog Status:

The human GeneID 2892 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gria3
Fold Change:		-1.19
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_032990.2	NP_116785.2	NC_005120.2 range: 3454528..3718485, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043204	perikaryon	Cellular Component	IDA (15844209)
GO:0043198	dendritic shaft	Cellular Component	IDA (12077196)
GO:0043197	dendritic spine	Cellular Component	IDA (12077196\|17207780)
GO:0043195	terminal button	Cellular Component	IDA (15844209)
GO:0043083	synaptic cleft	Cellular Component	IDA (17207780)
GO:0043025	cell soma	Cellular Component	IDA (12077196)
GO:0032279	asymmetric synapse	Cellular Component	IDA (12077196)
GO:0030425	dendrite	Cellular Component	IDA (15844209)
GO:0014069	postsynaptic density	Cellular Component	IDA (12077196\|17207780)
GO:0005624	membrane fraction	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	Molecular Function	IDA (11834304)
GO:0004970	ionotropic glutamate receptor activity	Molecular Function	IDA (11834304)