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Gene Information
Gene ID:29628
Full Name:glutamate receptor, ionotropic, AMPA3 (alpha 3)
Organism:Rattus norvegicus (Rat)
Genetic Location:Xq11
Physical Location:3454528-3718485 on NC_005120.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2892    Symbol (Name): GRIA3 (glutamate receptor, ionotrophic, AMPA 3)
Ortholog Status:The human GeneID 2892 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gria3
Fold Change:-1.19
P Value:0.009
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_032990.2NP_116785.2NC_005120.2 range: 3454528..3718485, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043204perikaryonCellular ComponentIDA (15844209)
GO:0043198dendritic shaftCellular ComponentIDA (12077196)
GO:0043197dendritic spineCellular ComponentIDA (12077196|17207780)
GO:0043195terminal buttonCellular ComponentIDA (15844209)
GO:0043083synaptic cleftCellular ComponentIDA (17207780)
GO:0043025cell somaCellular ComponentIDA (12077196)
GO:0032279asymmetric synapseCellular ComponentIDA (12077196)
GO:0030425dendriteCellular ComponentIDA (15844209)
GO:0014069postsynaptic densityCellular ComponentIDA (12077196|17207780)
GO:0005624membrane fractionCellular ComponentISS
GO:0005515protein bindingMolecular FunctionISS
GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityMolecular FunctionIDA (11834304)
GO:0004970ionotropic glutamate receptor activityMolecular FunctionIDA (11834304)
Other Database Cross Links
NCBI Entrez Gene:29628