ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

29659

Symbol:

P2rx4

Full Name:

purinergic receptor P2X, ligand-gated ion channel 4

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

12q16

Physical Location:

34943899-34961550 on NC_005111.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5025 Symbol (Name): P2RX4 (purinergic receptor P2X, ligand-gated ion channel, 4)

Ortholog Status:

The human GeneID 5025 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.7176
Original ID2:		P2rx4
Fold Change:		1.29
P Value:		0.00028
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031594.1	NP_113782.1	NC_005111.2 range: 34943899..34961550, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0030424	axon	Cellular Component	IDA (15476696)
GO:0030425	dendrite	Cellular Component	IDA (15476696)
GO:0043025	cell soma	Cellular Component	IDA (11160443\|15476696)
GO:0043195	terminal button	Cellular Component	IDA (15476696)
GO:0043197	dendritic spine	Cellular Component	IDA (11160443)
GO:0045177	apical part of cell	Cellular Component	ISS
GO:0045202	synapse	Cellular Component	IDA (15476696)
GO:0014069	postsynaptic density	Cellular Component	IDA (11160443\|15476696)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IDA (12819199)
GO:0008144	drug binding	Molecular Function	IDA (16282518)
GO:0004931	ATP-gated cation channel activity	Molecular Function	IDA (12819199\|16282518\|16934235)
GO:0004931	ATP-gated cation channel activity	Molecular Function	ISS
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0005507	copper ion binding	Molecular Function	IDA (12819199)
GO:0005524	ATP binding	Molecular Function	IDA (12819199\|16282518\|16934235)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0042311	vasodilation	Biological Process	ISS
GO:0006809	nitric oxide biosynthetic process	Biological Process	ISS
GO:0019228	regulation of action potential in neuron	Biological Process	IDA (12819199\|16282518\|16934235)
GO:0006811	ion transport	Biological Process	IEA
GO:0006816	calcium ion transport	Biological Process	ISS
GO:0051260	protein homooligomerization	Biological Process	IDA (15313628)
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process	ISS