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Gene Information
Gene ID:29659
Full Name:purinergic receptor P2X, ligand-gated ion channel 4
Organism:Rattus norvegicus (Rat)
Genetic Location:12q16
Physical Location:34943899-34961550 on NC_005111.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5025    Symbol (Name): P2RX4 (purinergic receptor P2X, ligand-gated ion channel, 4)
Ortholog Status:The human GeneID 5025 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.7176
Original ID2:P2rx4
Fold Change:1.29
P Value:0.00028
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031594.1NP_113782.1NC_005111.2 range: 34943899..34961550, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0030424axonCellular ComponentIDA (15476696)
GO:0030425dendriteCellular ComponentIDA (15476696)
GO:0043025cell somaCellular ComponentIDA (11160443|15476696)
GO:0043195terminal buttonCellular ComponentIDA (15476696)
GO:0043197dendritic spineCellular ComponentIDA (11160443)
GO:0045177apical part of cellCellular ComponentISS
GO:0045202synapseCellular ComponentIDA (15476696)
GO:0014069postsynaptic densityCellular ComponentIDA (11160443|15476696)
GO:0004872receptor activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIDA (12819199)
GO:0008144drug bindingMolecular FunctionIDA (16282518)
GO:0004931ATP-gated cation channel activityMolecular FunctionIDA (12819199|16282518|16934235)
GO:0004931ATP-gated cation channel activityMolecular FunctionISS
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005507copper ion bindingMolecular FunctionIDA (12819199)
GO:0005524ATP bindingMolecular FunctionIDA (12819199|16282518|16934235)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0042311vasodilationBiological ProcessISS
GO:0006809nitric oxide biosynthetic processBiological ProcessISS
GO:0019228regulation of action potential in neuronBiological ProcessIDA (12819199|16282518|16934235)
GO:0006811ion transportBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessISS
GO:0051260protein homooligomerizationBiological ProcessIDA (15313628)
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:29659