ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Scn1b

Full Name:

sodium channel, voltage-gated, type I, beta

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q21

Physical Location:

86162253-86172127 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6324 Symbol (Name): SCN1B (sodium channel, voltage-gated, type I, beta)

Ortholog Status:

The human GeneID 6324 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.4958
Original ID2:		Scn1b
Fold Change:		1.16
P Value:		0.00107
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017288.1	NP_058984.1	NC_005100.2 range: 86162253..86172127, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0005272	sodium channel activity	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006814	sodium ion transport	Biological Process	IEA