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Gene Information
Gene ID:29686
Symbol:Scn1b
Full Name:sodium channel, voltage-gated, type I, beta
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q21
Physical Location:86162253-86172127 on NC_005100.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6324    Symbol (Name): SCN1B (sodium channel, voltage-gated, type I, beta)
Ortholog Status:The human GeneID 6324 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.4958
Original ID2:Scn1b
Fold Change:1.16
P Value:0.00107
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017288.1NP_058984.1NC_005100.2 range: 86162253..86172127, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005272sodium channel activityMolecular FunctionIEA
GO:0031402sodium ion bindingMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006814sodium ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:29686
RGD:3631
Ensembl:ENSRNOG00000021102
dbSNP:Scn1b