ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gabrd

Full Name:

gamma-aminobutyric acid (GABA-A) receptor, subunit delta

Alias:

GABAA-RD|MGC105467

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q36

Physical Location:

172203055-172214963 on NC_005104.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2563 Symbol (Name): GABRD (gamma-aminobutyric acid (GABA) A receptor, delta)

Ortholog Status:

The human GeneID 2563 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		29689
Fold Change:		0.644
P Value:		0.0195
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017289.1	NP_058985.1	NC_005104.2 range: 172203055..172214963, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0004890	GABA-A receptor activity	Molecular Function	IDA (12356876)
GO:0005254	chloride channel activity	Molecular Function	IEA
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0004890	GABA-A receptor activity	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0007268	synaptic transmission	Biological Process	IDA (12356876)