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Gene Information
Gene ID:29748
Symbol:Ppp3r1
Full Name:protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Organism:Rattus norvegicus (Rat)
Chromosome:14
Genetic Location:14q22
Physical Location:98060301-98099091 on NC_005113.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5534    Symbol (Name): PPP3R1 (protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform)
Ortholog Status:The human GeneID 5534 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ppp3r1
Fold Change:-1.29
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017309.2NP_059005.1NC_005113.2 range: 98060301..98099091
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004721phosphoprotein phosphatase activityMolecular FunctionIDA (12135494)
GO:0005515protein bindingMolecular FunctionIPI (15120593)
GO:0005515protein bindingMolecular FunctionISS
GO:0001837epithelial to mesenchymal transitionBiological ProcessISS
GO:0006470protein amino acid dephosphorylationBiological ProcessIDA (12135494)
GO:0007507heart developmentBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:29748
RGD:69230
Ensembl:ENSRNOG00000022857
dbSNP:Ppp3r1