ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ywhae

Full Name:

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Alias:

14-3-3e

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q24

Physical Location:

63072127-63109832 on NC_005109.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7531 Symbol (Name): YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide)

Ortholog Status:

The human GeneID 7531 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		29753
Fold Change:		0.855
P Value:		0.019
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031603.1	NP_113791.1	NC_005109.2 range: 63072127..63109832

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042470	melanosome	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0019904	protein domain specific binding	Molecular Function	ISS
GO:0019904	protein domain specific binding	Molecular Function	IEA
GO:0019899	enzyme binding	Molecular Function	ISS
GO:0019899	enzyme binding	Molecular Function	IPI (8694795)
GO:0008426	protein kinase C inhibitor activity	Molecular Function	TAS (8694795)
GO:0005515	protein binding	Molecular Function	ISS
GO:0007165	signal transduction	Biological Process	TAS (8694795)
GO:0006605	protein targeting	Biological Process	ISS
GO:0021766	hippocampus development	Biological Process	ISS
GO:0021987	cerebral cortex development	Biological Process	ISS
GO:0035308	negative regulation of protein amino acid dephosphorylation	Biological Process	ISS
GO:0001764	neuron migration	Biological Process	ISS