ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Wwp1

Full Name:

WW domain containing E3 ubiquitin protein ligase 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q13

Physical Location:

34238504-34325950 on NC_005104.2, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Wwp1
Fold Change:		-1.12
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001024757.1	NP_001019928.1	NC_005104.2 range: 34238504..34325950, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0006464	protein modification process	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA