ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pin1

Full Name:

protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

8q13

Physical Location:

19668944-19682152 on NC_005107.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5300 Symbol (Name): PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)

Ortholog Status:

The human GeneID 5300 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.6291
Fold Change:		1.27
P Value:		0
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_216609.4	XP_216609.3	NC_005107.2 range: 19668944..19682152

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0016853	isomerase activity	Molecular Function	IEA
GO:0042127	regulation of cell proliferation	Biological Process	ISS