ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Map2k3

Full Name:

mitogen activated protein kinase kinase 3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q22

Physical Location:

47075215-47096627 on NC_005109.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5606 Symbol (Name): MAP2K3 (mitogen-activated protein kinase kinase 3)

Ortholog Status:

The human GeneID 5606 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Map2k3
Fold Change:		1.16
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_239239.3	XP_239239.2	NC_005109.2 range: 47075215..47096627

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0003674	molecular_function	Molecular Function	ND
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0004708	MAP kinase kinase activity	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0045860	positive regulation of protein kinase activity	Biological Process	ISS
GO:0042035	regulation of cytokine biosynthetic process	Biological Process	ISS
GO:0006954	inflammatory response	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0000165	MAPKKK cascade	Biological Process	ISS
GO:0000187	activation of MAPK activity	Biological Process	ISS
GO:0060048	cardiac muscle contraction	Biological Process	ISS