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Gene Information
Gene ID:303200
Full Name:mitogen activated protein kinase kinase 3
Organism:Rattus norvegicus (Rat)
Genetic Location:10q22
Physical Location:47075215-47096627 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5606    Symbol (Name): MAP2K3 (mitogen-activated protein kinase kinase 3)
Ortholog Status:The human GeneID 5606 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Map2k3
Fold Change:1.16
P Value:0.002
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_239239.3XP_239239.2NC_005109.2 range: 47075215..47096627
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0003674molecular_functionMolecular FunctionND
GO:0004672protein kinase activityMolecular FunctionIEA
GO:0004708MAP kinase kinase activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0005524ATP bindingMolecular FunctionIEA
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessISS
GO:0045860positive regulation of protein kinase activityBiological ProcessISS
GO:0042035regulation of cytokine biosynthetic processBiological ProcessISS
GO:0006954inflammatory responseBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0000165MAPKKK cascadeBiological ProcessISS
GO:0000187activation of MAPK activityBiological ProcessISS
GO:0060048cardiac muscle contractionBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:303200