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Gene Information
Gene ID:303369
Full Name:ligase III, DNA, ATP-dependent
Organism:Rattus norvegicus (Rat)
Genetic Location:10q26
Physical Location:71000286-71021397 on NC_005109.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3980    Symbol (Name): LIG3 (ligase III, DNA, ATP-dependent)
Ortholog Status:The human GeneID 3980 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Lig3
Fold Change:1.14
P Value:0.01
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001012011.1NP_001012011.1NC_005109.2 range: 71000286..71021397
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0003910DNA ligase (ATP) activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0016874ligase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0006310DNA recombinationBiological ProcessIEA
GO:0006281DNA repairBiological ProcessIEA
GO:0006260DNA replicationBiological ProcessIEA
GO:0033151V(D)J recombinationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:303369