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Gene Information
Gene ID:304917
Full Name:serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
Organism:Rattus norvegicus (Rat)
Genetic Location:13q22
Physical Location:76548455-76562723 on NC_005112.2
Gene Type:protein-coding
Human Ortholog:GeneID: 462    Symbol (Name): SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1)
Ortholog Status:The human GeneID 462 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Serpinc1
Fold Change:1.17
P Value:0.009
Note:Differential expression between ethanol and water groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001012027.1NP_001012027.1NC_005112.2 range: 76548455..76562723
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentIDA (7930519)
GO:0004867serine-type endopeptidase inhibitor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIDA (7362830)
GO:0005515protein bindingMolecular FunctionISS
GO:0007584response to nutrientBiological ProcessIDA (17123684)
GO:0050728negative regulation of inflammatory responseBiological ProcessIMP (16095456)
Other Database Cross Links
NCBI Entrez Gene:304917