ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Serpinc1

Full Name:

serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q22

Physical Location:

76548455-76562723 on NC_005112.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 462 Symbol (Name): SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1)

Ortholog Status:

The human GeneID 462 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Serpinc1
Fold Change:		1.17
P Value:		0.009
Note:		Differential expression between ethanol and water groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001012027.1	NP_001012027.1	NC_005112.2 range: 76548455..76562723

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	IDA (7930519)
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IDA (7362830)
GO:0005515	protein binding	Molecular Function	ISS
GO:0007584	response to nutrient	Biological Process	IDA (17123684)
GO:0050728	negative regulation of inflammatory response	Biological Process	IMP (16095456)