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Gene Information
Gene ID:3060
Symbol:HCRT
Full Name:hypocretin (orexin) neuropeptide precursor
Alias:OX|PPOX
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17q21
Physical Location:37589603-37590995 on NC_000017.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:HCRT
Dataset Information
Name:18477577
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:HCRT
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001524.1NP_001515.1NC_000017.9 range: 37589603..37590995, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005791rough endoplasmic reticulumCellular ComponentIEA
GO:0008021synaptic vesicleCellular ComponentTAS (9419374)
GO:0030054cell junctionCellular ComponentIEA
GO:0031410cytoplasmic vesicleCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0007218neuropeptide signaling pathwayBiological ProcessIEA
GO:0007268synaptic transmissionBiological ProcessTAS (9419374)
GO:0007631feeding behaviorBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:3060
HGNC:4847
Ensembl:ENSG00000161610
MIM:602358
HPRD:03836
HuGE Navigator:3060
dbSNP:HCRT
GeneCard:HCRT
AceView:HCRT