ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Flnb

Full Name:

filamin, beta

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

15p14

Physical Location:

18949022-19082574 on NC_005114.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2317 Symbol (Name): FLNB (filamin B, beta (actin binding protein 278))

Ortholog Status:

The human GeneID 2317 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.1761
Fold Change:		1.2
P Value:		0.00758
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_224561.4	XP_224561.4	NC_005114.2 range: 18949022..19082574, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0001725	stress fiber	Cellular Component	ISS
GO:0005575	cellular_component	Cellular Component	ND
GO:0005925	focal adhesion	Cellular Component	ISS
GO:0003674	molecular_function	Molecular Function	ND
GO:0005515	protein binding	Molecular Function	ISS
GO:0007519	skeletal muscle development	Biological Process	ISS
GO:0008150	biological_process	Biological Process	ND