ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cacna2d3

Full Name:

calcium channel, voltage-dependent, alpha2/delta subunit 3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

16p16

Physical Location:

4173411-5059573 on NC_005115.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55799 Symbol (Name): CACNA2D3 (calcium channel, voltage-dependent, alpha 2/delta subunit 3)

Ortholog Status:

The human GeneID 55799 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cacna2d3
Fold Change:		1.33
P Value:		0.004
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Cacna2d3
Fold Change:		1.13
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_175595.2	NP_783185.1	NC_005115.2 range: 4173411..5059573, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005891	voltage-gated calcium channel complex	Cellular Component	TAS (12606261)
GO:0005262	calcium channel activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005246	calcium channel regulator activity	Molecular Function	TAS (12606261)
GO:0005245	voltage-gated calcium channel activity	Molecular Function	IDA (12606261)
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006816	calcium ion transport	Biological Process	IDA (12606261)
GO:0006816	calcium ion transport	Biological Process	IEA