ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Kifc3

Full Name:

kinesin family member C3

Alias:

KRP4|MGC156699

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

19p13

Physical Location:

10317917-10354363 on NC_005118.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3801 Symbol (Name): KIFC3 (kinesin family member C3)

Ortholog Status:

The human GeneID 3801 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Kifc3
Fold Change:		-1.19
P Value:		0.001
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Kifc3
Fold Change:		-1.15
P Value:		0.007
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_240978.4	XP_240978.4	NC_005118.2 range: 10317917..10354363

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005874	microtubule	Cellular Component	IEA
GO:0005875	microtubule associated complex	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	ISS
GO:0005871	kinesin complex	Cellular Component	ISS
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0003777	microtubule motor activity	Molecular Function	IEA
GO:0007017	microtubule-based process	Biological Process	ISS
GO:0007018	microtubule-based movement	Biological Process	IEA
GO:0007030	Golgi organization and biogenesis	Biological Process	ISS