| Gene Information |
| Gene ID: | | 307858 |
| Symbol: | | Ldhd |
| Full Name: | | lactate dehydrogenase D |
| Alias: | | Ac2-202 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 19 |
| Genetic Location: | | 19q12 |
| Physical Location: | | 41532047-41553995 on NC_005118.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 197257 Symbol (Name): LDHD (lactate dehydrogenase D) |
| Ortholog Status: | | The human GeneID 197257 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Ldhd | | Fold Change: | | 1.13 | | P Value: | | 0.005 | | Note: | | Differential expression between ethanol and saccharin groups in nucleus accumbens |
| | Gene Information | | Original ID1: | | Ldhd | | Fold Change: | | 1.15 | | P Value: | | 0.001 | | Note: | | Differential expression between ethanol and saccharin groups in nucleus accumbens |
| | Dataset Information | | Name: | | 18405950 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens and amygdala | | Phenotype: | | Ethanol self-administration, alcohol-preferring | | Publication: | | Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed | | Summary: | | The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005739 | mitochondrion | Cellular Component | ISS | |
| GO:0005743 | mitochondrial inner membrane | Cellular Component | IDA (11955284) | |
| GO:0005515 | protein binding | Molecular Function | ISS | |
| GO:0016491 | oxidoreductase activity | Molecular Function | IEA | |
| GO:0050660 | FAD binding | Molecular Function | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 307858 |
| RGD: | | 1308107 |
| Ensembl: | | ENSRNOG00000019036 |
| dbSNP: | | Ldhd |
