ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pnkp

Full Name:

polynucleotide kinase 3'-phosphatase

Alias:

MGC94448

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q22

Physical Location:

95330454-95335467 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 11284 Symbol (Name): PNKP (polynucleotide kinase 3'-phosphatase)

Ortholog Status:

The human GeneID 11284 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pnkp
Fold Change:		1.14
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001004259.1	NP_001004259.1	NC_005100.2 range: 95330454..95335467

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity	Molecular Function	ISS
GO:0046403	polynucleotide 3'-phosphatase activity	Molecular Function	ISS
GO:0016301	kinase activity	Molecular Function	IEA
GO:0019201	nucleotide kinase activity	Molecular Function	ISS
GO:0042769	DNA damage response, detection of DNA damage	Biological Process	ISS
GO:0016311	dephosphorylation	Biological Process	ISS
GO:0006979	response to oxidative stress	Biological Process	ISS
GO:0006281	DNA repair	Biological Process	ISS
GO:0046939	nucleotide phosphorylation	Biological Process	ISS