| Gene Information |
| Gene ID: | | 308993 |
| Symbol: | | Sephs2 |
| Full Name: | | selenophosphate synthetase 2 |
| Alias: | | MGC156840 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 1 |
| Genetic Location: | | 1q36 |
| Physical Location: | | 186535714-186537760 on NC_005100.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 22928 Symbol (Name): SEPHS2 (selenophosphate synthetase 2) |
| Ortholog Status: | | The human GeneID 22928 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Rn.11447 | | Fold Change: | | 1.73 | | P Value: | | 0.00001 | | Note: | | Lower levels in the hippocampus of iP than iNP rats |
| | Dataset Information | | Name: | | 15660665 | | Method: | | Microarray | | Tissue: | | Hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed | | Summary: | | The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01). |
| | Gene Information | | Original ID1: | | Sephs2 | | Fold Change: | | -1.61 | | Tissue: | | Accumbens |
| | Gene Information | | Original ID1: | | Sephs2 | | Fold Change: | | -1.39 | | Tissue: | | Amygdala |
| | Gene Information | | Original ID1: | | Sephs2 | | Fold Change: | | -1.47 | | Tissue: | | Hippocampus |
| | Gene Information | | Original ID1: | | Sephs2 | | Fold Change: | | -1.45 | | Tissue: | | Caudate-putamen |
| | Dataset Information | | Name: | | 17517326 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed | | Summary: | | The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0003824 | catalytic activity | Molecular Function | IEA | |
| GO:0004756 | selenide, water dikinase activity | Molecular Function | IEA | |
| GO:0005524 | ATP binding | Molecular Function | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 308993 |
| RGD: | | 1308827 |
| Ensembl: | | ENSRNOG00000030632 |
| dbSNP: | | Sephs2 |
