ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Bin1

Full Name:

bridging integrator 1

Alias:

ALP-1|Amphl|BRAMP-2|SH3P9

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 B1|18 14.0 cM

Physical Location:

32536870-32595393 on NC_000084.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 274 Symbol (Name): BIN1 (bridging integrator 1)

Ortholog Status:

The human GeneID 274 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Bin1
Original ID2:		U60884

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0006897	endocytosis	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0030100	regulation of endocytosis	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0045786	negative regulation of cell cycle	Biological Process	IEA